NUP98
MIM.601021
Nucleoporin-98 is a 98 kDa component of the nuclear pore complex implicated in nucleo-cytoplasmic transport.
Pathology
fusion genes formation by translocations
- NUP98/HOXD13 fusion gene in acute myeloid leukemia
- NUP98/PRRX2 fusion gene in acute myeloid leukemia in acute myelomonocytic leukemia (M4 ANLL) by t(9;11)(q34;p15) (9q34 and 11p15)
- NUP98/NSD1 fusion gene
- NUP98/NSD3 fusion gene
- NUP98/PMX1 fusion gene
- NUP98/HOXA9 fusion gene
- NUP98/TOP1 fusion gene
- NUP98/DDX10 fusion gene
- NUP98/HOXD11 fusion gene
- NUP98/HOXC13 fusion gene
- NUP98/ADD3 fusion gene
- NUP98/PRRX2 fuison gene in acute myelomonocytic leukemia (M4 ANLL) by t(9;11)(q34;p15) (9q34.1 and 11p15)
- NUP98/JARID1A (12p13) by t(4;11)(q13;p15) in leukemias (#16419055#)
References
van Zutven LJ, Onen E, Velthuizen SC, van Drunen E, von Bergh AR, van den Heuvel-Eibrink MM, Veronese A, Mecucci C, Negrini M, de Greef GE, Beverloo HB. Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. Genes Chromosomes Cancer. 2006 May;45(5):437-46. PMID: #16419055#
A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. Gervais C, Mauvieux L, Perrusson N, Helias C, Struski S, Leymarie V, Lioure B, Lessard M. Leukemia 2005; 19: 145-148. PMID: #15496970#