KIT
MIM.164920
| See also CD117 | IHCDB |
Expression in cells
c-KIT positive spermatogonia
Expression in tumors (Exemples)
chromophobe renal cell carcinoma (100%)
renal oncocytoma (100%)
Pathology
KIT activating mutations in
- gastrointestinal stromal tumor (GIST)
- mastocytosis
- testicular germ-cell tumors (TGCT)
Use in diagnosis
Differential diagnosis between chromophobe renal cell carcinoma and the granular variant of clear cell renal cell carcinoma (#15832088#)
KIT is an independent prognostic marker for pancreatic endocrine tumors. (#19574886#)
References
Expression in normal cells
Immunohistochemical expression analysis of Cx43, Cx26, c-KIT and PlAP in contralateral testis biopsies of patients with non-seminomatous testicular germ cell tumor. Steiner M, Weipoltshammer K, Viehberger G, Meixner EM, Lunglmayr G, Schöfer C. Histochem Cell Biol. 2011 Jan;135(1):73-81. PMID: #21161545#
Expression in tumors
KIT is an Independent Prognostic Marker for Pancreatic Endocrine Tumors: A Finding Derived From Analysis of Islet Cell Differentiation Markers. Zhang L, Smyrk TC, Oliveira AM, Lohse CM, Zhang S, Johnson MR, Lloyd RV. Am J Surg Pathol. 2009 Jul 1. PMID: #19574886#
Wang HY, Mills SE. KIT and RCC Are Useful in Distinguishing Chromophobe Renal Cell Carcinoma From the Granular Variant of Clear Cell Renal Cell Carcinoma. Am J Surg Pathol. 2005 May;29(5):640-646. PMID: #15832088#