colorectal tumorigenesis
Chromosomal instability
The most common form of genomic instability observed in colorectal cancer is chromosomal instability (CIN), whose molecular bases remain to be determined.
Reviews
de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer. 2004 Oct;4(10):769-80. PMID: #15510158#
Reymond MA, Steinert R, Kahne T, Sagynaliev E, Allal AS, Lippert H. Expression and functional proteomics studies in colorectal cancer. Pathol Res Pract. 2004;200(2):119-27. PMID: #15237920#
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer. 2003 Sep;3(9):695-701. PMID: #12951588#
Kerr D. Clinical development of gene therapy for colorectal cancer. Nat Rev Cancer. 2003 Aug;3(8):615-22. PMID: #12894249#
Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med. 2003 Mar 6;348(10):919-32. PMID: #12621137#
Rhodes JM, Campbell BJ. Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared. Trends Mol Med. 2002 Jan;8(1):10-6. PMID: #11796261#
Bustin SA, Jenkins PJ. The growth hormone-insulin-like growth factor-I axis and colorectal cancer. Trends Mol Med. 2001 Oct;7(10):447-54. PMID: #11597519#
Remvikos Y, Muleris M, Salmon RJ, Dutrillaux B. Colorectal carcinogenesis: from chromosomal evolution pathways to molecular pathogenesis. Cancer Genet Cytogenet. 1997 Jan;93(1):63-73. PMID: #9062582#
References
Habermann JK, Paulsen U, Roblick UJ, Upender MB, McShane LM, Korn EL, Wangsa D, Kruger S, Duchrow M, Bruch HP, Auer G, Ried T. Stage-specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesis. Genes Chromosomes Cancer. 2007 Jan;46(1):10-26. PMID: #17044061#