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VSX1

Pathology

- germline mutations in

  • keratoconus type 1 (MIM.148300)
  • posterior polymorphous corneal dystrophy (PPCD1) (MIM.122000)
  • association wide interpupillary distance, abnormal corneal endothelium, unusual pinnae, partially to completely empty sella turcica, posterior fossa cyst, anterior encephalocele, and/or hydrocephalus