PHB
MIM.176705 17q21
Prohibitin is a 30-kD intracellular, antiproliferative protein.
Localization
Mitochondrial Prohibitin is localized to the mitochondria where it might have a role in the maintenance of mitochondrial function and protection against senescence.
Nuclear-localized PHB has potential roles as a tumor suppressor, an anti-proliferative protein, a regulator of cell-cycle progression and in apoptosis.
PHB might also function as a cell-surface receptor for an as-yet0unidentified ligand.
Pathology
mutations in mammary carcinomas (breast cancer)
References
Mishra S, Murphy LC, Nyomba BL, Murphy LJ. Prohibitin: a potential target for new therapeutics. Trends Mol Med. 2005 Apr;11(4):192-7. PMID: #15823758#