NTN1

Netrin-1 is a diffusible protein made by floor plate cells; it can attract spinal commissural axons and repel trochlear axons in vitro.

Axonal guidance

Embryologic experiments in both vertebrates and invertebrates provide evidence that developing axons are guided to their targets in the nervous system by the combined actions of attractive and repulsive guidance cues.

One family of putative guidance cues for developing axons are the netrins, large (approximately 70-80 kD), soluble proteins that show homology in their amino termini to portions of the extracellular matrix molecule laminin (MIM.150320) and that have been implicated in axon guidance through distinct and complementary lines of evidence in worms, flies, and vertebrates.

See also

 NTNs (netrins)

References

 Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer. 2004 Dec;4(12):978-87. PMID: 15573119

References

 Mazelin, L.; Bernet, A.; Bonod-Bidaud, C.; Pays, L.; Arnaud, S.; Gespach, C.; Bredesen, D. E.; Scoazec, J.-Y.; Mehlen, P. :
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431: 80-84, 2004. PubMed ID : 15343335

 Meyerhardt, J. A.; Caca, K.; Eckstrand, B. C.; Hu, G.; Lengauer, C.; Banavali, S.; Look, A. T.; Fearon, E. R. : Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell Growth Diff. 10: 35-42, 1999. PubMed ID : #9950216 #

 Park, K. W.; Crouse, D.; Lee, M.; Karnik, S. K.; Sorensen, L. K.; Murphy, K. J.; Kuo, C. J.; Li, D. Y. : The axonal attractant netrin-1 is an angiogenic factor. Proc. Nat. Acad. Sci. 101: 16210-16215, 2004. PubMed ID : 15520390