STXs
Syntaxins function in the vesicle fusion process in the presynaptic active zone. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis.
Members
| STX1A | STX1B | STX2 | STX3 | STX4 | STX5 | STX6 | STX7 | STX8 | STX9 | STX10 |
| STX11 | STX12 | STX13 | STX14 | STX15 | STX16 | STX17 | STX18 |
syntaxin-1A (MIM.186590)
syntaxin-1B (MIM.186590)
syntaxin-2 (epimorphin) (MIM.132350)
syntaxin-3 (MIM.600876)
syntaxin-4 (MIM.186591)
syntaxin-5 (MIM.603189)
syntaxin-6 (MIM.603944)
syntaxin-7 (MIM.603217)
syntaxin-8 (MIM.604203)
syntaxin-9 (MIM.)
syntaxin-10 (MIM.603765)
syntaxin-11 (MIM.605014)
syntaxin-12 (MIM.606892) = syntaxin-13 (MIM.606892)
syntaxin-14 (MIM.)
Pathology
STX11 germline mutations in familial hemophagocytic lymphohistiocytosis type-4 (FHL4) (#15703195#)
See also
syntaxins-containing vesicles
syntaxins-binding proteins
insintaxin transport