CHFR
MIM.605209
A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain forkhead-associated (FHA) domains are cell cycle checkpoints.
Animal models
CHFR null mice (#15793587#)
Pathology
Expression of the mitotic checkpoint protein Chfr is lost in 20-50% of primary tumors and tumor cell lines.