CD59
MIM.107271 11p13
Without adequate protection, the cells of the human body would be susceptible to destruction by the complement system. The main defense against complement lysis is a molecule called protectin (CD59) that is widely distributed in human tissues.
Pathology
inherited complete deficiency of CD59
- paroxysmal nocturnal hemoglobinuria (#1691667#)
- hemolytic anemia
- thrombosis
- cerebral infarction
References
Scheinin T, Bohling T, Halme L, Kontiainen S, Bjorge L, Meri S. Decreased expression of protectin (CD59) in gut epithelium in ulcerative colitis and Crohn’s disease. Hum Pathol. 1999 Dec;30(12):1427-30. PMID: #10667419#