hepatic infantile hemangioendothelioma
Subtypes
hepatic infantile hemangioma (GLUT1+)
type 2 infantile hepatic hemangioendothelioma
Synopsis
88% presented before age 3 months
44% of antenatal diagnosis
asymptomatic hepatomegaly (13%)
high-output cardiac failure (69%)
consumptive coagulopathy (75%)
anemia (75%)
Associations
heterotopic intrathoracic liver associated with diaphragmatic hernia (#3596593#)
mesenchymal hamartoma (#15018455#)
Beckwith-Wiedemann syndrome (#1570237#)
cutaneous hemangiomas (63%)
disseminated hemangiomatosis (13%)
Forms
fetal tumor (44%)
Complications
high-output cardiac failure (69%)
consumptive coagulopathy (75%)
anemia (75%)
References
Drut R, Drut RM. Expression of p57KIP2 in infantile hemangioma. J Mol Histol. 2005 Mar;36(3):195-7. PMID: #15900410#
Cerar A, Dolenc-Strazar ZD, Bartenjev D. Infantile hemangioendothelioma of the liver in a neonate. Immunohistochemical observations. Am J Surg Pathol. 1996 Jul;20(7):871-6. PMID: #8669536#
Samuel M, Spitz L. Infantile hepatic hemangioendothelioma: the role of surgery. J Pediatr Surg. 1995 Oct;30(10):1425-9. PMID: #8786479#
Drut R, Drut RM, Toulouse JC. Hepatic hemangioendotheliomas, placental chorioangiomas, and dysmorphic kidneys in Beckwith-Wiedemann syndrome. Pediatr Pathol. 1992 Mar-Apr;12(2):197-203. PMID: #1570237#