MAP2Ks
Mitogen-activated protein kinases (MAPKs), also known as extracellular signal-regulated kinases (ERKs), are thought to act as an integration point for multiple biochemical signals because they are activated by a wide variety of extracellular signals.
They are rapidly phosphorylated on threonine and tyrosine residues, and are highly conserved in evolution.
Kinases of mitogen-activated protein kinases (MAP2Ks) are critical protein kinases that lie upstream of MAP kinases (MAPKs) and stimulates their enzymatic activity of MAP kinases.
Members
| MAP2K1 | MAP2K2 | MAP2K3 | MAP2K4 | MAP2K5 | MAP2K6 | MAP2K7 |
Pathology
germline mutations of MAP2K1 in cardiofaciocutaneous syndrome (MIM.115150).