CMV hepatitis
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CMV is the most important cause of opportunistic hepatitis in immunocompromised patients. 20% of patients with liver allograft develop CMV hepatitis.
Synopsis
cytomegalic cytopathic effects
- enlarged cells
- cytomegalic nuclear inclusions
- large, glassy masses in the nucleus, separated by a clear halo from the irregularly thickened nuclear membrane
- cytomegalic cytoplasmic inclusions
- basophilic or amphophilic granules of various size
- inclusion-bearing cells maybe encircled by a cluster of neutrophils
+/- confluent foci of hepatocellular necrosis
unusual massive hepatic necrosis
Three clinicopathological patterns
mononucleosis-like disease
See also
cytomegalovirus
CMV infections
viral hepatitis
Hepatitis
Videos
Congenital CMV disease by Washington Deceit
References
Theise ND, Conn M, Thung SN. Localization of cytomegalovirus antigens in liver allografts over time. Hum Pathol. 1993 Jan;24(1):103-8. PMID: #8380273#