CD15
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||image_reduire{0,60}|inserer_attribut{alt,CD15 immunolabeling in lymphocyte-rich classic Hodgkin lymphoma})
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CD15 is a carbohydrate adhesion molecule (not a protein) that mediates phagocytosis and chemotaxis.
CD15 synthesis is directed by FUT9 (MIM.104230) in lymphoid cells and mature granulocytes and by FUT4 (MIM.606865) in promyelocytes and monocytes. See FUT4 (MIM.104230) and FUT9.
Immunochemistry
membranous labeling
diffuse cytoplasmic or Golgi staining in classic Hodgkin lymphoma
Diagnosis
Hodgkin lymphoma
- Reed-Sternberg cells
help differentiate between classic Hodgkin lymphoma (CD15+) and anaplastic large cell lymphoma (usually CD15-)
help differentiate between adenocarcinoma (CD15+) and mesothelioma (CD15-)
Positive immunostaining
Reed-Sternberg cells (classic Hodgkin lymphoma and follicular Hodgkin lymphoma)
15% of peripheral T cell lymphoma
50% of carcinomas
5% of B cell lymphomas
- some B-CLL
- some pre-pre B ALL
- some AML
- occasionally anaplastic large cell lymphoma (usually negative)
Negative immunostaining
non-activated lymphocytes
basophils
platelets
erythroid cells
L& H cells in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)
diffuse large B cell lymphoma
granulocytic sarcoma
systemic mastocytosis
pleural epithelial mesothelioma
hairy cell leukemia
malignant meningioma
malignant histiocytes
Langerhans cell histiocytosis
See also
CD15