vesical carcinomas
Definition: Malignant epithelial tumors of the bladder.
Bladder cancer ranks fifth in cancer incidence in the Western Hemisphere and is a leading cause of death from genitourinary cancer, with 145,000 deaths annually worldwide (mostly vesical carcinomas).
Types (Examples)
vesical transitional cell carcinoma
vesical squamous cell carcinoma
Oncogenetics
Bladder tumors constitute a very heterogeneous disease. Superficial tumors are characterized by a high prevalence of FGFR3 mutations and chromosome 9 alterations. High-grade and muscle-invasive tumors are characterized by Tp53 mutations and aneuploidy.
PIK3CA mutations
- PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. (#16885334#)
References
Haynes MD, Martin TA, Jenkins SA, Kynaston HG, Matthews PN, Jiang WG. Tight junctions and bladder cancer. Int J Mol Med. 2005 Jul;16(1):3-9. PMID: #15942671#