PMCAs
The human plasma membrane Ca(2+)-ATPase isoforms (PMCAs) are encoded by at least 4 separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts.
These enzymes are members of the P class of ion-motive ATPases; they form an acylphosphate intermediate as part of the reaction mechanism.
PMCAs remove bivalent calcium ions from eukaryotic cells and plays a critical role in intracellular calcium homeostasis by its capacity for removing calcium ions from cells against very large concentration gradients.
See also
SERCAs