megacystis
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Etioogy
fetal urethral obstruction (obstructive megacystis)
- meconium in the urinary bladder (congenital rectovesical fistula)
- urethral atresia (agenesis of the posterior urethra) with or without anorectal agenesis
- posterior urethral valve
non-obstructive megacystis
- intestinal neuronal dysplasia
- vesical myopathy (visceral myopathy)
- megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS)
- trisomy 18
- megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS)
chromosomal anomalies
- trisomy 13
- trisomy 18
- trisomy 21
Mouse models
mgb mouse: transgenic mutant mouse model with in utero megabladder, hydroureteronephrosis, chronic renal failure secondary to obstructive uropathy (primary defect in bladder smooth muscle development) (#17202422#)
See also
Prune-Belly sequence
Case records
Case record #10087
Case record #11183: megacystis-microcolon syndrome
Case record #11598: Megacystis in urethral obstruction sequence (UOS) with prune belly syndrome
References
McHugo J, Whittle M. Enlarged fetal bladders: aetiology, management and outcome. Prenat Diagn. 2001 Nov;21(11):958-63. PMID: #11746149#