Tourette syndrome
Gilles de la Tourette syndrome (GTS) is characterized by multiple motor and phonic tics and high comorbidity rates with other neurobehavioral disorders. It is hypothesized that frontal-subcortical pathways and a complex genetic background are involved in the etiopathogenesis of the disorder.
Susceptibility
germline mutations of SLITRK1 at 17q25
References
Grados MA, Walkup JT. A new gene for Tourette’s syndrome: a window into causal mechanisms? Trends Genet. 2006 Jun;22(6):291-3. PMID: #16678301#