IDs
ID proteins contain a helix-loop-helix (HLH) motif and regulate tissue-specific transcription within several cell lineages. They do not bind DNA directly, but inhibit lineage commitment by binding basic helix-loop-helix (bHLH) transcription factors through their HLH motif. ID proteins contribute to cell growth, senescence, differentiation, angiogenesis, invasion and migration.
Members
| ID1 | ID2 | ID3 | ID4 |
See also
HLH proteins
References
Perk J, Iavarone A, Benezra R. Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer. 2005 Aug;5(8):603-14. PMID: #16034366#
Fong S, Debs RJ, Desprez PY. Id genes and proteins as promising targets in cancer therapy. Trends Mol Med. 2004 Aug;10(8):387-92. PMID: #15310459#