gliomatosis peritonei
Gliomatosis peritonei is a rare condition that occurs almost exclusively in the setting of ovarian immature teratoma.
It is characterized by the occurrence of nodules of mature glial tissues in the peritoneum.
It is controversial whether glial tissues are derived from maturation of the associated teratomatous tissue that has implanted in the peritoneum, or glial differentiation of subperitoneal stem cells.
In 5 informative cases, the normal tissues showed a heterozygous pattern in the microsatellite loci, the associated teratomas showed a homozygous pattern, and the glial tissues showed a heterozygous pattern. (#15188134#)
Thus, gliomatosis peritonei is genetically unrelated to the associated teratoma but is probably derived from nonteratomatous cells, such as through metaplasia of submesothelial cells.
References
Kwan MY, Kalle W, Lau GT, Chan JK. Is gliomatosis peritonei derived from the associated ovarian teratoma? Hum Pathol. 2004 Jun;35(6):685-8. PMID: #15188134#