gout

Digital slides

 UI:859 - Interphalangeal joint of toe - Gout tophus
 Gouty Tophi in Sesamoid Bone of Foot by Ed Euthman.

Digital slides

 UI:859 - Interphalangeal joint of toe - Gout tophus.

Images

 Gouty Tophi in Sesamoid Bone of Foot by Ed Euthman.

 Deposits of destroyed uric acid crystals seen as amorphus eosinophilic material

• https://twitter.com/Valdebran/status/748320406440800257
• https://twitter.com/RyanHickMD/status/722120072072794112
• https://twitter.com/VishwasParekh/status/709152199495061505

Definition: Gout is a disorder of uric-acid metabolism.

Synopsis

 gouty tophi (gouty tophus)

• The tophus represent accumulation of monosodium urate derived from chronic hyperurecemia seen in the disorder called gout.
• Surrounding chronic inflammatory cells, fibrosis, and foreign body giant cells can be noted.

Localization

 gouty arthritis
 intestinal gouty nodulosis (15257557)
 gouty panniculitis

Susceptibility

 SLC2A9 (GLUT9) at Chr.4
 ABCG2 at Chr.4
 4q25 (15252757)