inhibitors of apoptosis proteins
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Definition: Group of proteins that demonstrate significant inhibition of apoptosis and caspases.
Inhibitor of apoptosis proteins (IAPs) are upregulated in cancers and suppress cell death, in part, through their ability to directly inhibit caspases. The functions of some IAPs are counteracted by the cell death inducer, second mitochondrial-derived activator of caspases/direct IAP binding protein with low pI (Smac/DIABLO).
Pathology
Inhibitor of apoptosis proteins are differentially expressed in B-cell lymphomas.
Members
| BIRC1 | BIRC2 | BIRC3 | BIRC4 | BIRC5 | BIRC6 | BIRC7 |
| HIAP1 | HIAP2 |
XIAP, HIAP1 (601721), and HIAP2 (601712) belong to a human multigene family whose members show extensive homology to baculovirus IAPs (inhibitor of apoptosis proteins) and encode proteins that demonstrate significant inhibition of apoptosis.
References
Ren Y, Akyurek N, Schlette E, Rassidakis GZ, Medeiros LJ. Expression of Smac/DIABLO in B-cell non-Hodgkin and Hodgkin lymphomas. Hum Pathol. 2006 Nov;37(11):1407-13. PMID: #16949641#
Vischioni B, van der Valk P, Span SW, Kruyt FA, Rodriguez JA, Giaccone G. Expression and localization of inhibitor of apoptosis proteins in normal human tissues. Hum Pathol. 2006 Jan;37(1):78-86. PMID: #16360419#
Andersen MH, Becker JC, Straten P. Regulators of apoptosis: suitable targets for immune therapy of cancer. Nat Rev Drug Discov. 2005 May;4(5):399-409. PMID: #15864269#
Senderowicz AM. Targeting cell cycle and apoptosis for the treatment of human malignancies. Curr Opin Cell Biol. 2004 Dec;16(6):670-8. PMID: #15530779#
Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 2004 Oct 15;64(20):7183-90. PMID: #15492230#