sacrococcygeal teratoma
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Sacrococcygeal teratoma (SCT) is the most common tumor of the newborn with an incidence of 1 in 35,000 to 40,000 live births.
In the newborn, the sacrococcygeal site is located at the base of the tailbone (coccyx), is the most common location of teratomas in newborns.
Variants
malignant transformation
- amplification at 8q and 12p (#20113846#)
Cytogenetics
constitutional 7q deletion (#14663834#)
constitutional trisomy 2p (#14663834#)
constitutional t(12;15)(q13;q25) pat (#12165446#)
- MESDC2/SENP1 fusion gene (#15917269#)
constitutional partial trisomy 10q (10q24.3—>qter) and partial monosomy 17p (p13.3—>pter) (#17295347#)
Predisposition
Currarino syndrome
- presacral teratoma
- anterior meningocele
- sacral agenesis
- anorectal malformation
See also
congenital germ cell tumors (CGCTs) or neonatal germ cell tumors (NGCTs)
malignant transformation of sacrococcygeal teratoma (#20113846#)
References
Malignant transformation of an untreated congenital sacrococcygeal teratoma: a amplification at 8q and 12p detected by comparative genomic hybridization. Golas MM, Gunawan B, Raab BW, Füzesi L, Lange B. Cancer Genet Cytogenet. 2010 Feb;197(1):95-8. PMID: #20113846#
Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. Drut R. Histopathology. 2009 May;54(6):763; PMID: #19438750#
Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. Busch C, Oppitz M, Wehrmann M, Schweizer P, Drews U. Histopathology. 2008 May;52(6):717-30.PMID: #18439155#
Heerema-McKenney A, Harrison MR, Bratton B, Farrell J, Zaloudek C. Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol. 2005 Jan;29(1):29-38. PMID: #15613854#
Sebire NJ, Fowler D, Ramsay AD. Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases. Fetal Pediatr Pathol. 2004 Sep-Dec;23(5-6):295-303. PMID: #16137166#
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. Le Caignec C, Winer N, Boceno M, Delnatte C, Podevin G, Liet JM, Quere MP, Joubert M, Rival JM. Prenat Diagn. 2003 Dec 15;23(12):981-4. PMID: #14663834#
Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP. Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children’s Cancer Group. Am J Surg Pathol. 1998 Sep;22(9):1115-24. PMID: #9737245#
Sacrococcygeal teratoma in a fetus with prenatally diagnosed partial trisomy 10q (10q24.3—>qter) and partial monosomy 17p (p13.3—>pter). Batukan C, Ozgun MT, Basbug M, Caglayan O, Dundar M, Murat N. Prenat Diagn. 2007 Apr;27(4):365-8. PMID: #17295347#