ESRs
Members
estrogen receptor alpha (ESR1) (MIM.133430)
estrogen receptor beta (ESR2) (MIM.601663)
Cancer
Oestrogen receptor-alpha (ERalpha or ESR1)-regulated transcription in breast cancer cells involves protein co-factors that contribute to the regulation of chromatin structure.
These include co-factors with the potential to regulate histone modifications such as acetylation or methylation, and therefore the transcriptional state of target genes.
Much of the information regarding the interaction of specific co-factors with ER has been generated by studying specific promoter regions.
References
Green KA, Carroll JS. Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state. Nat Rev Cancer. 2007 Sep;7(9):713-22. PMID: #17721435#
Barros RP, Machado UF, Gustafsson JA. Estrogen receptors: new players in diabetes mellitus. Trends Mol Med. 2006 Sep;12(9):425-431. PMID: #16890492#