chromosomal segregation
Proper chromosome segregation is required to maintain the appropriate number of chromosomes from one cell generation to the next and to prevent aneuploidy, the condition in which a cell has gained or lost one or several chromosomes during cell division.
Aneuploidy is a hallmark associated with birth defects and cancer, and is observed at relatively high frequencies in human somatic cells.
Recent studies in mammalian tissue culture cells suggest that the persistence of kinetochore-microtubule misattachments through mitosis is a major cause of chromosome mis-segregation and aneuploidy.
Furthermore, studies in mice and humans suggest that small changes in the expression, rather than complete inactivation, of genes encoding specific proteins might be associated with aneuploidy in living organisms.
Abnormal chromosomal segregation
Inactivation in human cells of several components of the Pes1-Bop1 complex (BOP1, GRWD1, PES1, ORC6L, and RPL3), involved in ribosome biogenesis, altered chromosome segregation. (#16804918#)
See also
chromosomal instability
References
Cimini D, Degrassi F. Aneuploidy: a matter of bad connections. Trends Cell Biol. 2005 Aug;15(8):442-51. PMID: #16023855#
Kapoor TM. Chromosome segregation: correcting improper attachment. Curr Biol. 2004 Dec 14;14(23):R1011-3. PMID: #15589138#
Draviam VM, Xie S, Sorger PK. Chromosome segregation and genomic stability. Curr Opin Genet Dev. 2004 Apr;14(2):120-5. PMID: #15196457#