CD10
| PathologyOutlines | HGNC |
See also: MME
Definition: Cell membrane metallopeptidase expressed by early B, pro-B and pre-B lymphocytes, and by lymph node germinal centers. Also widely distributed in normal tissue, including brush border of small bowel mucosa. Also expressed in neoplasms (epithelial cells and stroma).
Expression in normal cells
normal and neoplastic endometrial stromal cells
biliary canaliculi (#2144860#)
Wolffian-type epithelium and Wolffian epithelial cells
- Mullerian-type epithelium is CD10-
kidney : glomeruli (podocytes, parietal epithelial cells), brush border of proximal tubules
Expression in lesions
- paratesticular cysts with benign epithelial proliferations of wolffian origin
- wolffian glandular inclusions in inguinal hernia sacs
Expression in tumors
lymbloblastic lymphoma and lymphoblastic leukemias
follicular lymphoma, Burkitt lymphoma
mesonephric tumors
- mesonephric adenocarcinoma of the uterine corpus (#11717545#)
endometrial stromal nodule, endometrial stromal sarcoma
hepatocellular carcinoma (canalicular immunostaining) (#11688465#)
clear cell renal cell carcinoma
Pathology
CD10 is useful in the assessment of peripheral sheath tumors and could give evidence that atypical myxoid and/or diffuse neurofibromas, sometimes histologically difficult to distinguish from low-grade MPNST, represent not only a histological but also an immunohistochemical continuum with MPNST.
- Neurofibromas are sporadic or associated with type 1 neurofibromatosis (NF1), with a higher risk of malignant progression.
Functions
90-110 kDa cell membrane metallopeptidase at 3q21-27 which inactivates bioactive peptides, including bombesin.
In epithelial cells, CD10 loss from methylation leads to increased cell migration, cell growth and cell survival, contributing to neoplastic development and progression (J Pediatr Hematol Oncol 2010;32:2).
CD10 is found on non-T ALL cells which derive from pre-B lymphocytes, and in germinal center-related non-Hodgkin lymphoma such as Burkitt lymphoma and follicular lymphoma, but not on leukemia cells or lymphomas which originate in more mature B cells. (J Pediatr Hematol Oncol 2010;32:2)
Links
References
Diagnostic and prognostic value of CD10 in peripheral nerve sheath tumors. Cabibi D, Zerilli M, Caradonna G, Schillaci L, Belmonte B, Rodolico V. Anticancer Res. 2009 Aug;29(8):3149-55. PMID: #19661328#
Nistal M, Gonzalez-Peramato P, Serrano A, Vega-Perez M, De Miguel MP, Regadera J. Paratesticular cysts with benign epithelial proliferations of wolffian origin. Am J Clin Pathol. 2005 Aug;124(2):245-51. PMID: #16040296#
Cerilli LA, Sotelo-Avila C, Mills SE. Glandular inclusions in inguinal hernia sacs: morphologic and immunohistochemical distinction from epididymis and vas deferens. Am J Surg Pathol. 2003 Apr;27(4):469-76. PMID: #12657931#
Cerilli LA, Sotelo-Avila C, Mills SE. Glandular inclusions in inguinal hernia sacs: morphologic and immunohistochemical distinction from epididymis and vas deferens. Am J Surg Pathol. 2003 Apr;27(4):469-76. PMID: #12657931#
Toki T, Shimizu M, Takagi Y, Ashida T, Konishi I. CD10 is a marker for normal and neoplastic endometrial stromal cells. Int J Gynecol Pathol. 2002 Jan;21(1):41-7. PMID: #11781522#
Ordi J, Romagosa C, Tavassoli FA, Nogales F, Palacin A, Condom E, Torne A, Cardesa A. CD10 expression in epithelial tissues and tumors of the gynecologic tract: a useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Am J Surg Pathol. 2003 Feb;27(2):178-86. PMID: #12548163#
Ordi J, Nogales FF, Palacin A, Marquez M, Pahisa J, Vanrell JA, Cardesa A. Mesonephric adenocarcinoma of the uterine corpus: CD10 expression as evidence of mesonephric differentiation. Am J Surg Pathol. 2001 Dec;25(12):1540-5. PMID: #11717545#