ETV4
MIM.600711
Pathology
EWSR1/ETV4 fusion gene by a t(17;22)(q12;q12) in
- extra-osseous Ewing sarcoma
- undifferentiated sarcoma of infancy (#8834175#)
TMPRSS2/ETV4 gene fusion in prostatic carcinoma (prostate cancer) (#17390040#, #16585160#)
overexpression in tumors
- pulmonary carcinomas (non-small cell lung cancer)
- colorectal adenocarcinomas (colon cancer)
- oral squamous cell carcinoma (OSCC)
See also
ETVs and ETSs
References
Winnes M, Lissbrant E, Damber JE, Stenman G. Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer. Oncol Rep. 2007 May;17(5):1033-6. PMID: #17390040#
Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D, Helgeson BE, Cao X, Wei JT, Rubin MA, Shah RB, Chinnaiyan AM. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res. 2006 Apr 1;66(7):3396-400. PMID: #16585160#
Szuhai K, Ijszenga M, Tanke HJ, Rosenberg C, Hogendoorn PC. Molecular cytogenetic characterization of four previously established and two newly established Ewing sarcoma cell lines. Cancer Genet Cytogenet. 2006 Apr 15;166(2):173-9. PMID: #16631476#
Shindoh M, Higashino F, Kohgo T. E1AF, an ets-oncogene family transcription factor. Cancer Lett. 2004 Dec 8;216(1):1-8. PMID: #15500943#
Ishida S, Yoshida K, Kaneko Y, Tanaka Y, Sasaki Y, Urano F, Umezawa A, Hata J, Fujinaga K. The genomic breakpoint and chimeric transcripts in the EWSR1-ETV4/E1AF gene fusion in Ewing sarcoma. Cytogenet Cell Genet. 1998;82(3-4):278-83. PMID: #9858836#
Urano F, Umezawa A, Yabe H, Hong W, Yoshida K, Fujinaga K, Hata J. Molecular analysis of Ewing’s sarcoma: another fusion gene, EWS-E1AF, available for diagnosis. Jpn J Cancer Res. 1998 Jul;89(7):703-11. PMID: #9738976#
Urano F, Umezawa A, Hong W, Kikuchi H, Hata J. A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing’s sarcoma. Biochem Biophys Res Commun. 1996 Feb 15;219(2):608-12. PMID: #8605035#
Kaneko Y, Yoshida K, Handa M, Toyoda Y, Nishihira H, Tanaka Y, Sasaki Y, Ishida S, Higashino F, Fujinaga K. Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy. Genes Chromosomes Cancer. 1996 Feb;15(2):115-21. PMID: #8834175#