osteochondrodysplasias
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Definition: Genetic diseases of skeletal development.
Classification
Chondrodysplasias (ostechondrodysplasias with defects of the tubular bones or axial skeleton)
- short-trunk chondrodysplasias
- achondrogenesis
- hypochondrogenesis
- spondyloepiphyseal dysplasia congenita
- Kniest dysplasia
- dyssegmental dysplasia
- atelosteogenesis (spondylohumerofemoral hypoplasia)
- boomerang dysplasia
- fibrochondrogenesis
- Schneckenbecken dysplasia
- non-short-trunk chondrodysplasia with platyspondyly
- achondroplasia
- thanatophoric dysplasia (Cases 10552 and 10556)
- thanatophoric dysplasia with cloverleaf skull
- metatropicdysplasia
- opsismodysplasia
- spondylodysplasias (PLSDs) (Torrence, San Diego, Luton)
- short-rib dysplasias (with or without polydactyly)
- asphyxiating thoracic dysplasia (Jeune syndrome)
- Ellis-van Creveld syndrome (chondroectodermal dysplasia)
- short-rib dysplasias with polydactyly (Short rib-polydactyly syndromes) (Case 10557 and 10558)
- unclassified short-rib dysplasias
- chondrodysplasia punctata group (stippled epiphysis, chondrodysplasia calcificans congenita)
- Greenberg dysplasia
- dappled diaphysis dysplasia
- rhizomelic type chondrodysplasia punctata
- Conradi-Hünermann type chondrodysplasia punctata
- tibial-metacarpal type chondrodysplasia punctata
- brachytelephalangic type chondrodysplasia punctata
- campomelic dysplasia
- kyphomelic dysplasia (short-limbed capmtomelic dysplasia)
- diastrophic dysplasia
- Larsen syndrome
- Desbuqois syndrome
- mesomelic dysplasias
- acromesomelic dysplasia
- otopalatodigital syndrome
osteodysplasias with abnormal bone density
- osteogenesis imperfecta
- osteopetrosis
- pycnodysostosis
- osteosclerosis (dominant osteosclerosis type Stanescu)
- infantile cortical hyperostosis (Coffey disease)
osteochondrodysplasias with defective mineralization
- hypophosphatasia
osteochondrodysplasias with metabolic anomalies
- mucolipidoses (MLs)
- mucolipidosis II (ML2) (I-cell disease)
- mucolipidosis III (ML3)
- mucopolysaccharidoses (MPSs)
- mucopolysaccharidosis I-H
- mucopolysaccharidosis I (MPS1)
- mucopolysaccharidosis II (MPS2)
- mucopolysaccharidosis III (MPS3)
- mucopolysaccharidosis IV (MPS4)
- mucopolysaccharidosis VI (MPS6)
- mucopolysaccharidosis VII (MPS7) (beta-glucuronidase deficiency)
- GM1 gangliosidosis
- sialidosis/galactosialidosis
- mannosidosis
- fucosidosis
- aspartylglucosaminuria
- sialic acid storgae disease
unclassified osteochondrodysplasias
- atelosteogenesis type II (McALister dysplasia)
- Glasgow round femoral inferior epiphysis chondrodysplasia
- Dapppled diaphyseal dysplasia
- Greenberg dysplasia
- lethal brittle bone syndrome
- Raine syndrome
- dysplastic cortical hyperostosis
Variants
lethal osteochondrodysplasias
osteochondrodysplasias with predominant metaphyseal involvement
osteochondrodysplasias with predominant epiphyseal involvement
osteochondrodysplasias with predominant diaphyseal involvement
osteochondrodysplasias with major spinal involvement
osteochondrodysplasias with multiple dislocations
osteochondrodysplasias with predominant involvement of single sites or segments
- spine
- rhizomelic
- peripheral
osteochondrodysplasias with decreased bone density
- osteogenesis imperfecta (OIs)
- idiopathic osteoporosis
- geroderma osteodysplasticum
- Stuve-Wiedemann syndrome
osteochondrodysplasias with increased bone density
osteochondrodysplasias due to disorganized development of bone constituents
osteolyses
Case records
Case 10552: Thanatophoric dysplasia
Case 10556: Thanatophoric dysplasia
Case 10557: Short rib-polydactyly syndrome
Case 10558: Short rib-polydactyly syndrome
Case 10610: Achondrogenesis type 2