giant cell fibroblastoma

Definition: Phenotypic variant of dermatofibrosarcoma protuberans (DFSP) sharing the same COL1A1/PDGFB fusion gene.

Synopsis

 Spindle and multinucleated giant cells in a loose myxoid stroma:

Examples

 giant cell fibroblastoma

• https://twitter.com/JCandidoXavier/status/1188771734767460352

Cytogenetics

 t(17;22)(q22;q13) creating COL1A1/PDGFB fusion protein

Molecular biology

 COL1A1-PDGFB fusion protein by t(17;22)(q22;q13) ( COL1A1 at 17q22 and PDGFB at 22q13 )

See also

 fusion genes
 fusion proteins