vulvar squamous cell carcinoma
Squamous precancerous lesions and invasive squamous cell carcinomas (SCCs) of the lower female genital tract are etiologically linked to human papillomavirus (HPV) infection and appertain to the complex of the multicentric lower genital tract squamous neoplasia.
Unlike in uterine cervix, the majority of vulvar SCCs are HPV DNA negative with TP53 gene mutations emerging in the environment of vulvar dermatoses such as lichen sclerosus (LS) and lichen simplex chronicus (LSC) as the probable main etiologic factor.
Subtypes
vulvar verrucous carcinoma
Vulvar verrucous carcinoma is a rare variant of squamous cell carcinoma of the vulva that afflicts older women and is characterized by a well-differentiated morphology with minimal nuclear atypia.
References
Skapa P, Zamecnik J, Hamsikova E, Salakova M, Smahelova J, Jandova K, Robova H, Rob L, Tachezy R. Human papillomavirus (HPV) profiles of vulvar lesions: possible implications for the classification of vulvar squamous cell carcinoma precursors and for the efficacy of prophylactic HPV vaccination. Am J Surg Pathol. 2007 Dec;31(12):1834-43. PMID: #18043037#
Nascimento AF, Granter SR, Cviko A, Yuan L, Hecht JL, Crum CP. Vulvar Acanthosis With Altered Differentiation: A Precursor to Verrucous Carcinoma? Am J Surg Pathol. 2004 May;28(5):638-643. PMID: #15105653#