proteasome inhibitors
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Examples
MG132
PAthology
Multiple myeloma cells are unusually sensitive to inhibitors of the proteasome, a cellular organelle that specifically degrades unwanted and misfolded proteins, and proteasome inhibitor drugs have shown promise in patients.
References
Jiang YH, Beaudet AL. Human disorders of ubiquitination and proteasomal degradation. Curr Opin Pediatr. 2004 Aug;16(4):419-26. PMID: #15273504#
Ciechanover A, Ben-Saadon R. N-terminal ubiquitination: more protein substrates join in. Trends Cell Biol. 2004 Mar;14(3):103-6. PMID: #15055197#