lipodystrophies
Lipodystrophy is characterized by altered partition of adipose tissue.
Etiology
genetic diseases (congenital generalized lipodystrophy)
- Dunnigan-type familial partial lipodystrophy (FPLD) and partial lipodystrophy type A: mutations in LMNA gene coding for nuclear membrane lamin-A/C
- mandibuloacral dysplasia-associated lipodystrophy.
autoimmune diseases
drug-induced lipodystrophy
metabolic disorders
- insulin resistance
- hyperlipidemia
- diabetes
References
Garg A. Acquired and inherited lipodystrophies. N Engl J Med. 2004 Mar 18;350(12):1220-34. PMID: #15028826#
Hegele RA. Molecular basis of partial lipodystrophy and prospects for therapy. Trends Mol Med. 2001 Mar;7(3):121-6. PMID: #11286783#