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GAPs

The weak intrinsic GTPase activity of RAS proteins is greatly enhanced by the action of GTPase-activating proteins (GAPs). GAP is an effector of RAS oncogene action.

Specific GTPase-activating proteins that play regulatory roles in this enzymatic process have been identified for RAS homologous protein

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ARHG RAP1A RASA1 RASA2 RAP1GAP SIPA1