centrilobular necrosis

Types

 centrilobular hepatocellular ballooning
 centrilobular focal liver cell necrosis
 centrilobular sinusoidal congestion
 centrilobular drop-out
 centrilobular hemorrhagic necrosis
 confluent lobular necrosis

Etiology

 acute liver allograft rejection (acute cellular rejection)

• acute centrilobular rejection
  • centrilobular necrosis in liver allograft
  • centrilobular lymphocytic infiltration

 autoimmune hepatitis
 hepatic veno-occlusive disease
 toxics

• acetaminophen intoxication
• Amanita mushroom poisoning

See also

 hepatic lesions

• centrilobular lesions

References

 Centrilobular necrosis in children after combined liver and small bowel transplantation. Lacaille F, Canioni D, Fournet JC, Revillon Y, Cezard JP, Goulet O. Transplantation. 2002 Jan 27;73(2):252-7. PMID: 11821740