dystrophin-glycoprotein complex
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Definition: The dystrophin-glycoprotein complex (DGC) connects the extracellular matrix to the cytoskeleton in skeletal muscle and many other tissues.
The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells.
There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD) (MIM.300377) and syntrophin (SNTA1) (MIM.601017), the alpha- and beta-dystroglycans (MIM.128239), and the sarcoglycans (e.g., SGCA; MIM.600119). The SSPN gene encodes sarcospan (MIM.601559), another member of the DGC.
Dystroglycan (DG) is an adhesion molecule composed of two subunits, alpha and beta, that are produced by the post-translational cleavage of a single precursor molecule. DG is a pivotal component of the dystrophin-glycoprotein complex.
See also
dystrophin-associated proteins