Home > A. Molecular pathology > MCM2
MCM2
Saturday 6 March 2004
ProEx C
BD ProEx C (ProEx C) is a recently developed immunocytochemical assay that targets the expression of topoisomerase II-alpha (TOP2A) and minichromosome maintenance protein-2 (MCM2), 2 genes shown to be overexpressed in cervical cancers.
ProEx C is a reliable marker for high-grade CIN that can be applied to tissue sections to confirm the diagnosis of high-grade CIN and to triage cases of atypical squamous metaplasia.
ProEx C may also have a potential role in triaging patients with low-grade CIN.
ProEx C expression patterns are similar to those for p16 and Ki67 with most discrepancies occurring in the CIN I category.
Pathology
ProEx C is a useful proliferation marker for high-grade VIN analogous to the staining patterns reported in high-grade cervical intraepithelial neoplasia. (20697251)
Links
References
Immunohistochemical Patterns of ProEx C in Vulvar Squamous Lesions: Detection of Overexpression of MCM2 and TOP2A. Chen H, Gonzalez JL, Brennick JB, Liu M, Yan S. Am J Surg Pathol. 2010 Sep;34(9):1250-7. PMID: 20697251
Tye BK. The MCM2-3-5 proteins: are they replication licensing factors? Trends Cell Biol. 1994 May;4(5):160-6. PMID: 14731643