p16

p16 is coded by gene CDKN2A .

Images

 p16 IHC positivity

• https://twitter.com/chioseasi/status/744960605396803584

Diagnostic use

 Distinction of endocervical adenocarcinomas and endometrial adenocarcinomas (15043304)

 low-grade squamous cervical lesions

p16 and L1 immunohistochemistry can be helpful for estimating the biologic potentiality of low-grade squamous cervical lesions. Particularly in cases in which the grade of the lesion is morphologically difficult to assess, the p16/L1 expression pattern could be useful for planning the clinical management of these women.

In contrast to anogenital HPV-associated lesions, positive p16 expression is not a reliable marker of high-risk α-HPV infection in Bowen disease cases, as it can be also detected in β-HPV infected and HPV-negative cases. (26913849)

See also

 CDKN2A