vesiculobullous and acantholytic reaction pattern

|PO|

Anomalies

 spongiosis: accumulation of extracellular fluid within epidermis with resultant separation of keratinocytes

• eczematous dermatitis
• allergic contact dermatitis
• miliaria

 acantholysis: loss of appropriate keratinocyte cell-cell contact

• pemphigus
• transient acantholytic dermatosis
• Hailey-Hailey
• Darier disease
• Grover disease / transient acantholytic dermatosis
• irritant dermatitis

 reticular degeneration: ballooning degeneration with secondary rupture and death of the keratinocytes

• viral infections
• eczematous dermatitis

 cytolysis : disruption of keratinocytes due to friction or heat

• EB simplex
• epidermolytic hyperkeratosis
• friction blister

 basement membrane zone disruption or destruction from primary structural deficiencies, humoral and cellular immunologic damage

• bullous pemphigoid
• cicatricial pemphigoid
• linear IgA
• dermatitis herpetiformis
• epidermolysis bullosa acquisita
• junctional epidermolysis bullosa
• epidermolysis bullosa dystrophica

See also

 cutaneous lesional patterns