Home > E. Pathology by systems > Digestive system > inflammatory fibroid polyp
inflammatory fibroid polyp
Friday 27 February 2004
Inflammatory Fibroid Polyps of the Gastrointestinal Tract
| WP |
Definition: Inflammatory fibroid polyps (IFPs) are rare mesenchymal tumors of the gastrointestinal tract that consist of spindle-shaped stromal cells and an inflammatory infiltrate rich in eosinophils. Their etiology and histogenesis remain unknown.
Inflammatory fibroid polyp, abbreviated IFP, is a benign abnormal growth of tissue projecting into the lumen of the gastrointestinal tract. The endoscopic differential diagnosis includes other benign, pre-malignant and malignant gastrointestinal polyps.
Images
Inflammatory fibroid polyp of the gastric antrum
Microscopy
IFPs consist of spindle cells that are concentrically arranged around blood vessels and have inflammation, especially eosinophils.They may have leiomyoma/schwannoma-like areas with nuclear palisading.
Immunochemistry
They typically stain with CD34 and vimentin, and, generally, do not stain with CD117 and S100.
CD34+ (14707872)
fascin+ (14707872)
cyclin-D1+ (14707872)
References
Inflammatory Fibroid Polyps of the Gastrointestinal Tract: Spectrum of Clinical, Morphologic, and Immunohistochemistry Features. Liu TC, Lin MT, Montgomery EA, Singhi AD. Am J Surg Pathol. 2013 Feb 15. PMID: 23426127
Pantanowitz L, Antonioli DA, Pinkus GS, Shahsafaei A, Odze RD. Inflammatory fibroid polyps of the gastrointestinal tract: evidence for a dendritic cell origin. Am J Surg Pathol. 2004 Jan;28(1):107-14. PMID: 14707872