danger theory

The self-non-self theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the "danger theory."

Authors assess the danger theory vis-à-vis recent experimental data on innate immunity, transplantation, cancers and tolerance to foreign entities, and try to elucidate more clearly whether danger is well defined.

Open references

 The danger theory: 20 years later. Pradeu T, Cooper EL. Front Immunol. 2012 Sep 17;3:287. doi : 10.3389/fimmu.2012.00287. eCollection 2012 PMID: 23060876