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siderotic regenerative nodule
Tuesday 6 November 2018
Definition : Large regenerative nodules in cirrhotic livers may accumulate iron and develop internal iron-poor foci of hyperplasia or malignancy.
The nodule-within-nodule sign, which reflects the unique histopathology of hepatocellular carcinoma in large siderotic regenerative nodules, is strongly suggestive of early hepatocellular carcinoma, even if serologic markers and biopsy results do not support this diagnosis.
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Paywall references
Hepatocellular carcinoma within siderotic regenerative nodules: appearance as a nodule within a nodule on MR images. Mitchell DG, Rubin R, Siegelman ES, Burk DL Jr, Rifkin MD. Radiology. 1991 Jan;178(1):101-3. PMID: 1845784
Iron-negative foci in siderotic macroregenerative nodules in human cirrhotic liver. A marker of incipient neoplastic lesions. Terada T, Nakanuma Y. Arch Pathol Lab Med. 1989 Aug;113(8):916-20. PMID: 2757493