hepatoid adenocarcinoma

Localization

 gallbladder (14674996)
 stomach (14560160, 12845645)
 ovary (12819394, 12421179)
 in Barrett’s esophagus (11940219)
 endometrium (11606109)
 lung : pulmonary hepatoid adenocarcinoma (10931226)
 colon : hepatoid adenocarcinoma of the colon (10813132)
 pancreas (10738216)
 urinary bladder (10431850)
 esophagus : esophageal hepatoid adenocarcinoma (26094198)

Immunochemistry

 alpha-fetoprotein+ (AFP+)

Differential diagnosis

 hepatocellular carcinoma
 hepatoid variants

• hepatoid variant of yolk sac tumor of the testis (11012991)
• ovarian hepatoid yolk sac tumours (10231422)

Associations

 malignant mixed Mullerian tumor of the uterus (14599882)

References

 Hameed O, Xu H, Saddeghi S, Maluf H. Hepatoid carcinoma of the pancreas: a case report and literature review of a heterogeneous group of tumors. Am J Surg Pathol. 2007 Jan;31(1):146-52. PMID: 17197931

 Terracciano LM, Glatz K, Mhawech P, Vasei M, Lehmann FS, Vecchione R, Tornillo L. Hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma: an immunohistochemical and molecular study of eight cases. Am J Surg Pathol. 2003 Oct;27(10):1302-12. PMID: 14508391