peripheral T-cell lymphoma
Immunochemsitry
CD30+/- (#14657710#)
CD15+/- (#14657710#)
Localization
nodal peripheral T-cell lymphoma
Variants
CD56+/CD3+ peripheral T-cell lymphoma (#15794680#)
peripheral T-cell lymphoma with nodular growth pattern (#12100523#)
peripheral T-cell lymphoma with follicular T-cell markers (#18779728#)
Associations
clonal B-cell populations
secondary Epstein-Barr virus (EBV) driven B-cell expansions
EBV-associated B-cell lymphoma
associated Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas (#17721185#)
- clonal/monotypic plasma cell proliferation
- clonal/monotypic large B-cell proliferation
- B-cell lymphoma with plasmacytic/plasmablastic differentiation
Cytogenetics
t(14;19)(q11;q13) in peripheral T-cell lymphoma (PTCL)
- involvement of the TRA@/TRD@ locus at 14q11 and PVRL2 at 19q13 (#17696193#)
CGH (#17044049#)
gains
- Chr.17 gain (17q11-q25 gains)
- Chr.8 gain (involving the MYC locus at 8q24)
- 22q gain
losses
- 13q losses
- Chr.9 losses (9p21-q33 losses)
See also
T-cell lymphomas
References
Balague O, Martinez A, Colomo L, Rosello E, Garcia A, Martinez-Bernal M, Palacin A, Fu K, Weisenburger D, Colomer D, Burke JS, Warnke RA, Campo E. Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: a phenomenon with distinctive clinicopathologic features. Am J Surg Pathol. 2007 Sep;31(9):1310-22. PMID: #17721185#
Thorns C, Bastian B, Pinkel D, Roydasgupta R, Fridlyand J, Merz H, Krokowski M, Bernd HW, Feller AC. Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: A matrix-based CGH approach. Genes Chromosomes Cancer. 2007 Jan;46(1):37-44. PMID: #17044049#