histiocytic infiltration

Examples

 histiocytic infiltration in atypical mycobacteriosis

• https://twitter.com/HGongoraJaraMD/status/799857814864859136

 lymphohistiocytic infiltration in digestive histoplasmosis

• https://twitter.com/zemekmd/status/1125250842007724032

 histiocytic infiltration in Erdheim-Chester disease

• https://twitter.com/judith_ferry/status/1110879322468962304

Etiology (examples)

 infectious diseases

• mycobacterioses
• mycoses / fungal diseases
  • histoplamosis

 histiocytosis / histiocytoses

• Langerhans histiocytosis
• xanthogranulomas
  • juvenile xanthogranuloma

• crystal storing histiocytosis

Localization

 histiocytic infiltrates of the skin / cutaneous histiocytic infiltrates

Diagnostic of histiocytic infiltration

 IHC : CD68 , CD1a , S100
 search for infections agents : Ziehl , PAS , Gram , Grocott , methenamine silver
 search for intracellulaire bodies :

• Michaelis-Guttman bodies in malkoplakia

A CD68- , CD1a+ , S100+, langerin+ IHC profile makes a diagnosis of Langherans cell histiocytosis.

A CD68+ , S100+ or S100- , CD1a- , langerin IHC profile suggests a diagnosis of non-Langerhans cell histiocytosis as juvenile xanthogranuloma or Erdheim-Chester diseuse .

The presence of of Michaelis-Guttman Bodies m’aies thé diagnosis of a malakoplakia.

 infectious agents in histiocytes

• The presence of an infections agent in the cytoplasm of histiocytes makes the diagnosis of an infections disease with histiocytic reation :
  • AARB with Ziehl : mycobacterosis as tuberculoses or lepra
  • deep fungal diseases as histoplasmosis

See also

 cellular infiltration
 histiocytoses