acinar-to-ductal metaplasia

Molecular biology

 shortened telomeres are found in PanIN-associated acinar-to-ductal metaplasias, but not in isolated acinar-to-ductal metaplasia lesions.

• These results indicate that isolated acinar-to-ductal metaplasias are not a precursor to PanIN.
• They support the hypothesis that PanIN-associated acinar-to-ductal metaplasias arise secondary to PanIN lesions.

See also

 PanIns / PanIn

Open references

 Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias.
Hong SM, Heaphy CM, Shi C, Eo SH, Cho H, Meeker AK, Eshleman JR, Hruban RH, Goggins M. Mod Pathol. 2011 Feb;24(2):256-66.
doi : 10.1038/modpathol.2010.181
PMID: 20871595