telomeres

Telomere replication

Telomere replication relies on a strong synergy between the conventional replication machinery, telomere protection systems, DNA-damage-response pathways and chromosomal organization.

Pathology

 telomeropathies
 telomere shortening
 telomere lengthening

Links

 Telomeres at Kimball’s Biology Pages

See also

 telomere length
 shortening of telomeres (short telomeres)
 telomerases
 telomere maintenance
 telomere dysfunction
 telomere complexes
 telomeric associations
 telomere crisis
 telomere binding proteins

Reviews

 Blasco MA. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet. 2005 Aug;6(8):611-22. PMID: 16136653

 Stewart SA. Telomere maintenance and tumorigenesis: an "ALT"ernative road. Curr Mol Med. 2005 Mar;5(2):253-7. PMID: 15974880

 Opitz OG. Telomeres, telomerase and malignant transformation. Curr Mol Med. 2005 Mar;5(2):219-26. PMID: 15974876

 Greenberg RA. Telomeres, crisis and cancer. Curr Mol Med. 2005 Mar;5(2):213-8. PMID: 15974875

 Mason PJ, Wilson DB, Bessler M. Dyskeratosis congenita — a disease of dysfunctional telomere maintenance. Curr Mol Med. 2005 Mar;5(2):159-70. PMID: 15974869

 Wong JM, Collins K. Telomere maintenance and disease. Lancet. 2003 Sep 20;362(9388):983-8. PMID: 14511933

 Feldser DM, Hackett JA, Greider CW. Telomere dysfunction and the initiation of genome instability. Nat Rev Cancer. 2003 Aug;3(8):623-7. PMID: 12894250

 Hahn WC. Role of telomeres and telomerase in the pathogenesis of human cancer. J Clin Oncol. 2003 May 15;21(10):2034-43. PMID: 12743159

 Djojosubroto MW, Choi YS, Lee HW, Rudolph KL. Telomeres and telomerase in aging, regeneration and cancer. Mol Cells. 2003 Apr 30;15(2):164-75. PMID: 12803478

 Blasco MA. Telomerase beyond telomeres. Nat Rev Cancer. 2002 Aug;2(8):627-33. PMID: 12154355

 Cervantes RB, Lundblad V. Mechanisms of chromosome-end protection. Curr Opin Cell Biol. 2002 Jun;14(3):351-6. PMID: 12067658

 Tzukerman M, Selig S, Skorecki K. Telomeres and telomerase in human health and disease. J Pediatr Endocrinol Metab. 2002 Mar;15(3):229-40. PMID: 11924925

 Shay JW, Zou Y, Hiyama E, Wright WE. Telomerase and cancer. Hum Mol Genet. 2001 Apr;10(7):677-85. PMID: 11257099

 Marciniak RA, Johnson FB, Guarente L. Dyskeratosis congenita, telomeres and human ageing. Trends Genet. 2000 May;16(5):193-5. PMID: 10782108

 Royle NJ. Telomeres and disease. J Pathol. 1996 Nov;180(3):233-5. PMID: 8958797

Physiology references

 Gilson E, Géli V. How telomeres are replicated. Nat Rev Mol Cell Biol. 2007 Oct;8(10):825-38. PMID: 17885666

 Hahn WC. Telomere and telomerase dynamics in human cells. Curr Mol Med. 2005 Mar;5(2):227-31. PMID: 15974877

 Harley CB. Telomerase therapeutics for degenerative diseases. Curr Mol Med. 2005 Mar;5(2):205-11. PMID: 15974874

 von Zglinicki T, Martin-Ruiz CM. Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med. 2005 Mar;5(2):197-203. PMID: 15974873

 Beeharry N, Broccoli D. Telomere dynamics in response to chemotherapy. Curr Mol Med. 2005 Mar;5(2):187-96. PMID: 15974872

 Zimmermann S, Martens UM. Telomere dynamics in hematopoietic stem cells. Curr Mol Med. 2005 Mar;5(2):179-85. PMID: 15974871

 Boukamp P. Skin aging: a role for telomerase and telomere dynamics? Curr Mol Med. 2005 Mar;5(2):171-7. PMID: 15974870

 Chang S. Modeling premature aging syndromes with the telomerase knockout mouse. Curr Mol Med. 2005 Mar;5(2):153-8. PMID: 15974868

 Hezel AF, Bardeesy N, Maser RS. Telomere induced senescence: end game signaling. Curr Mol Med. 2005 Mar;5(2):145-52. PMID: 15974867

 Crabbe L, Karlseder J. In the end, it’s all structure. Curr Mol Med. 2005 Mar;5(2):135-43. PMID: 15974866

 Hande MP. DNA repair factors and telomere-chromosome integrity in mammalian cells. Cytogenet Genome Res. 2004;104(1-4):116-22. PMID: 15162024

 Mathieu N, Pirzio L, Freulet-Marriere MA, Desmaze C, Sabatier L. Telomeres and chromosomal instability. Cell Mol Life Sci. 2004 Mar;61(6):641-56. PMID: 15052408

 Shay JW, Wright WE. Telomeres are double-strand DNA breaks hidden from DNA damage responses. Mol Cell. 2004 May 21;14(4):420-1. PMID: 15149591

 Purdy A, Su TT. Telomeres: not all breaks are equal. Curr Biol. 2004 Aug 10;14(15):R613-4. PMID: 15296775

 Mefford HC, Trask BJ. The complex structure and dynamic evolution of human subtelomeres. Nat Rev Genet. 2002 Feb;3(2):91-102. PMID: 11836503

 Kipling D, Cooke HJ. Beginning or end? Telomere structure, genetics and biology. Hum Mol Genet. 1992 Apr;1(1):3-6. PMID: 1301133

 Blackburn EH: Switching and signaling at the telomere. Cell 106:661, 2001.