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low-grade adenosquamous carcinoma
Tuesday 16 August 2016
mammary LGASC; Low-grade adenosquamous carcinoma of the breast
Definition: Low-grade adenosquamous carcinoma of the breast is an uncommon neoplasm of uncertain pathogenesis, clinical behavior, and malignant potential.
The largely indolent, but locally aggressive, clinical course of low-grade adenosquamous carcinoma of the breast has been described.
Although complete limited excision of small lesions may be curative, tumors greater than 3.0 cm may require more aggressive therapy.
Images
Low-grade adenosquamous carcinoma (a metaplastic carcinoma) often arise in association with sclerosing papilloma.
Differential diagnosis
mammary small glandular proliferation
- mammary tubular carcinoma (MTC)
- microglandular adenosis (MGA)
- radial scar
- low-grade adenosquamous carcinoma (LGASC)
- displaced epithelium
- syringomatous adenoma
References
Low-grade adenosquamous carcinoma of the breast. A clinocopathologic study of 32 cases with ultrastructural analysis. Van Hoeven KH, Drudis T, Cranor ML, Erlandson RA, Rosen PP. Am J Surg Pathol. 1993 Mar;17(3):248-58. PMID: 8434705
