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mammary small glandular proliferation
Wednesday 25 November 2009
small glandular proliferations of the breast
Definition: Small glandular proliferations of the breast encompass a variety of benign, atypical, and malignant lesions that show some overlapping morphologic features.
Myoepithelial stains are frequently used in the workup of these lesions in order to rule out or establish a diagnosis of invasive carcinoma. Some benign lesions show absent or diminished myoepithelial staining, and may represent an interpretative pitfall, particularly in small core biopsy samples.
The interpretation of myoepithelial stains in small glandular proliferations of the breast can, on some occasions, represent a challenge in diagnosing these
lesions.
Open references
Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry. 2016.
References
Invasive tubular carcinoma of the breast frequently is clonally related to flat epithelial atypia and low-grade ductal carcinoma in situ. Aulmann S, Elsawaf Z, Penzel R, Schirmacher P, Sinn HP. Am J Surg Pathol. 2009 Nov;33(11):1646-53.PMID: 19675453