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ovarian endometrioid carcinoma
Wednesday 10 August 2016
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Images
endometrioid adenocacinoma
- http://www.webpathology.com/image.asp?case=527&n;=8
- https://twitter.com/AltaherN88/status/832498235570782208
secretory features seen in ovarian endometrioid carcinoma
sertoliform endometrioid carcinoma
Macroscopy
Cystic, solid, hemorrhagic
Papillary formations are absent or inconspicuous
5% bilateral
Mean 11 cm, range 3-22 cm
Microscopy
Either non-cystic villoglandular pattern, glandular confluence or stromal disappearance
Stromal invasion is defined as confluent glandular growth, stromal disappearance or obvious stromal invasion
Resembles endometrial endometrioid adenocarcinoma ( endometrium ), usually well differentiated
50% have squamous metaplasia (morules or keratin pearls, formerly called adenoacanthomas), 40% of well differentiated tumors have adenofibromatous component
10% are associated with luteinized stroma cells
May contain luminal but not cytoplasmic mucin,
may have clear cells (but lacks the architecture of clear cell carcinoma, Am J Surg Pathol 2007;31:1203)
Vascular invasion rare
Variants
sertoliform endometrioid carcinoma
Differential Diagnosis
ovarian granulosa cell tumor or ovarian Sertoli-Leydig tumor
- usually younger patients with endocrine symptoms,
- no squamous metaplasia,
- no typical endometrioid features elsewhere,
- no mucin,
- no adenofibroma component,
- keratin negative
ovarian metastatis of a colonic carcinoma
- dirty necrosis,
- garland pattern,
- CDX2+, CK20+
ovarian metastatis of an endometrial adenocarcinoma
- high grade,
- bilateral,
- multinodular,
- surface implants,
- prominent angiolymphatic invasion within ovarian stroma
mixed endometrioid and mucinous ovarian carcinoma
- > 10% mucinous component
yolk sac tumor / endodermal sinus tumor
See also
ovarian carcinomas
