Home > A. Molecular pathology > H3F3A
H3F3A
Monday 8 August 2016
H3.3; H3
Pathology
H3-K27M mutation in H3F3A / mutated K27M-H3.3
- K27M mutation in H3F3A in ganglioglioma grade I with spontaneous malignant transformation
- BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology. (26487540)
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. (26399631)
ATRX immunostaining predicts IDH and H3F3A status in gliomas. (27311324)
See also
histone H3 pathway
- histone H3 oncogenic pathway
Open References
Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation. Orillac C, Thomas C, Dastagirzada Y, Hidalgo ET, Golfinos JG, Zagzag D, Wisoff JH, Karajannis MA, Snuderl M. Acta Neuropathol Commun. 2016 Aug 12;4(1):84. doi : 10.1186/s40478-016-0361-0
PMID: 27519587 Free
ATRX immunostaining predicts IDH and H3F3A status in gliomas. Ebrahimi A, Skardelly M, Bonzheim I, Ott I, Mühleisen H, Eckert F, Tabatabai G, Schittenhelm J.
Acta Neuropathol Commun. 2016 Jun 16;4(1):60. doi : 10.1186/s40478-016-0331-6 PMID: 27311324 Free
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.
Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N, Pagès M, Taylor KR, Saulnier P, Lacroix L, Mackay A, Jones C, Sainte-Rose C, Blauwblomme T, Andreiuolo F, Puget S, Grill J, Varlet P, Debily MA.
Acta Neuropathol. 2015 Dec;130(6):815-27. doi : 10.1007/s00401-015-1478-0
PMID: 26399631 Free