plakins
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Function
By connecting cytoskeletal elements to each other and to junctional complexes, the plakin family of cytolinkers plays a crucial role in orchestrating cellular development and maintaining tissue integrity.
Plakins are built from combinations of interacting domains that bind to microfilaments, microtubules, intermediate filaments, cell-adhesion molecules and members of the armadillo family.
Members
desmoplakins
periplakin (MIM.602871)
plectin (MIM.601282)
BPAG1 (MIM.113810)
envoplakin (MIM.601590)
Pathology
Plakins are involved in both inherited and autoimmune diseases that affect the skin, neuronal tissue, and cardiac and skeletal muscle.
References
Leung CL, Green KJ, Liem RK. Plakins: a family of versatile cytolinker proteins. Trends Cell Biol. 2002 Jan;12(1):37-45. PMID: #11854008#
Lai Cheong JE, Wessagowit V, McGrath JA. Molecular abnormalities of the desmosomal protein desmoplakin in human disease. Clin Exp Dermatol. 2005 May;30(3):261-6. PMID: #15807686#